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Article

Cell-type-specific gene regulation in migraine and its subtypes links genetic risk to brain structure.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Jun 2026

Dong Haoyang, Liu Mengge, Wu Qian, Deng Linlin, Liu Ying, Wang Haolin, Xu Bochen, Ren Haoran, Zheng Zhuoru, Wang Wenqin, Liu Feng, Wang Kaiyuan, Ma Juanwei

Abstract excerpt

Migraine is a highly prevalent and disabling neurological disorder characterized by marked clinical heterogeneity, particularly between migraine with aura (MA) and migraine without aura (MO). Although genome-wide association studies (GWASs) have identified numerous risk loci, the cell-type-specific regulatory mechanisms linking genetic variation to brain structure and migraine susceptibility remain unclear. We...

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PMID: 42128045
DOI: 10.1016/j.pnpbp.2026.111745

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