Article
Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.
PLoS biology - 1 Jul 2014
Kizhatil Krishnakumar, Ryan Margaret, Marchant Jeffrey K, Henrich Stephen, John Simon W M
Abstract excerpt
Schlemm's canal (SC) plays central roles in ocular physiology. These roles depend on the molecular phenotypes of SC endothelial cells (SECs). Both the specific phenotype of SECs and development of SC remain poorly defined. To allow a modern and extensive analysis of SC and its origins, we developed a new whole-mount procedure to visualize its development in the context of surrounding tissues. We then applied...
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