MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.

doi:10.1016/j.kint.2023.06.018

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Article

MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.

Kidney international - 1 Sept 2023

Wang Yan-Na, Gan Ting, Qu Shu, Xu Lin-Lin, Hu Yong, Liu Li-Jun, Shi Su-Fang, Lv Ji-Cheng, Tsoi Lam C, Patrick Matthew T, He Kevin, Berthier Celine C, Xu Hu-Ji, Zhou Xu-Jie, Zhang Hong

Abstract excerpt

Multiple genome-wide association studies (GWASs) have reproducibly identified the MTMR3/HORMAD2/LIF/OSM locus to be associated with IgA nephropathy (IgAN). However, the causal variant(s), implicated gene(s), and altered mechanisms remain poorly understood. Here, we performed fine-mapping analyses based on GWAS datasets encompassing 2762 IgAN cases and 5803 control individuals, and identified rs4823074 as the...

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PMID: 37414396
DOI: 10.1016/j.kint.2023.06.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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