Article
TLR1 polymorphism rs4833095 as a risk factor for IgA nephropathy in a Chinese Han population: A case-control study.
Oncotarget - 13 Dec 2016
Gao Jie, Wei Linting, Wei Jiali, Yao Ganglian, Wang Li, Wang Meng, Liu Xinghan, Dai Cong, Jin Tianbo, Dai Zhijun, Fu Rongguo
Abstract excerpt
Toll-like receptors (TLRs) are a family of transmembrane receptors, and play a vital role in recognizing invading pathogens and activating innate immunity. Previous studies indicated that TLR1 single nucleotide polymorphisms (SNPs) might be associated with the risk of IgA nephropathy (IgAN). This study aims to investigate the relationship between TLR1 SNPs (rs4833095 and rs5743557) and IgAN in a Chinese Han...
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