Article
Causal associations of sarcopenia-related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study.
Aging cell - 1 Sept 2023
Ye Chaojie, Kong Lijie, Wang Yiying, Zheng Jie, Xu Min, Xu Yu, Li Mian, Zhao Zhiyun, Lu Jieli, Chen Yuhong, Wang Weiqing, Ning Guang, Bi Yufang, Wang Tiange
Abstract excerpt
The causal influence of sarcopenia on cardiometabolic disease and Alzheimer's disease and whether and to what extent insulin resistance plays a mediating role therein were unclear. We performed two-step, two-sample Mendelian randomization applying genetic instruments of sarcopenia-related traits based on GWASs from the UK Biobank (up to 461,026 European participants) to examine their causal associations with six...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.