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Article

Genetic Association and Potential Mediators between Sarcopenia and Coronary Heart Disease: A Bidirectional Two-Sample, Two-Step Mendelian Randomization Study.

Nutrients - 1 Jul 2023

He Junyi, Huang Mingkai, Li Nana, Zha Lingfeng, Yuan Jing

Abstract excerpt

OBJECTIVE: To elucidate the bidirectional correlation of sarcopenia with coronary heart disease (CHD), as well as to investigate the mediating role of cardiometabolic factors and inflammatory biomarkers, a bidirectional two-sample, two-step Mendelian randomization (MR) study was conducted. METHODS: Summary statistics were obtained from genome-wide association studies (GWAS). In our bidirectional two-sample MR,...

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PMID: 37447340
DOI: 10.3390/nu15133013
PMCID: PMC10346809

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