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Article

The causal relationship between sarcopenia-related traits and ischemic stroke: Insights from univariable and multivariable Mendelian randomization analyses.

CNS neuroscience & therapeutics - 1 May 2024

Song Jiahao, Zhou Da, Li Jingrun, Wang Mengqi, Jia Lina, Lan Duo, Song Haiqing, Ji Xunming, Meng Ran

Abstract excerpt

AIMS: The causal relationship between sarcopenia-related traits and ischemic stroke (IS) remains poorly understood. This study aimed to explore the causal impact of sarcopenia-related traits on IS and to identify key mediators of this association. METHODS: We conducted univariable, multivariable two-sample, and two-step Mendelian randomization (MR) analyses using genome-wide association study (GWAS) data. This...

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Identifiers

PMID: 38757378
DOI: 10.1111/cns.14759
PMCID: PMC11099748

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