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Article

Genetic associations and mediating effects of insulin resistance between hypertension and sarcopenia: A bidirectional two-sample Mendelian randomization study.

Experimental gerontology - 1 May 2026

Zou Jingfeng, Zhang Liyin, Li Shaotian, Hu Shanshan, Tian Chunhui, Liu Yiting, Yin Yilan, Yan Mi, Nie Guqiao, Peng Wen

Abstract excerpt

OBJECTIVE: Hypertension and sarcopenia are major global public health problems among the aging society. This study aims to explore the causal associations and mediating effects of insulin resistance (IR) between hypertension and sarcopenia. METHODS: A bidirectional two-step Mendelian randomization (MR) was applied to determine the causal mediating role of IR in the pathway between hypertension and four sarcopenia...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 41791434
DOI: 10.1016/j.exger.2026.113086

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