Article

Imprints of tumor mutation burden on chromosomes and relation to cancer risk in humans: A pan-cancer analysis

2020-04-21

Abstract excerpt

Cancers, resulting in uncontrolled cell proliferation, are driven by accumulation of somatic mutations. Genome-wide sequencing has produced a catalogue of millions of somatic mutations, which contain the evolutionary history of the cancers. However, the connection between the mutation accumulation and disease development and risks is poorly understood. Here, we analyzed more than 1,200,000 mutations from 5,000 can...

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Literature Corpus work: 8b56612b-7e43-59ed-a205-2a61506bc5f1
DOI: 10.1101/2020.04.20.050989

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