Article
Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder.
Sleep - 1 Aug 2017
Barber Thomas R, Lawton Michael, Rolinski Michal, Evetts Samuel, Baig Fahd, Ruffmann Claudio, Gornall Aimie, Klein Johannes C, Lo Christine, Dennis Gary, Bandmann Oliver, Quinnell Timothy, Zaiwalla Zenobia, Ben-Shlomo Yoav, Hu Michele T M
Abstract excerpt
Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is the most specific marker of prodromal alpha-synucleinopathies. We sought to delineate the baseline clinical characteristics of RBD and evaluate risk stratification models. Methods: Clinical assessments were performed in 171 RBD, 296 control, and 119 untreated Parkinson's (PD) participants. Putative risk measures were assessed as predictors of...
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