Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis.

JAMA cardiology - 1 Jan 2018

Harrison Seamus C, Holmes Michael V, Burgess Stephen, Asselbergs Folkert W, Jones Gregory T, Baas Annette F, van 't Hof F N, de Bakker Paul I W, Blankensteijn Jan D, Powell Janet T, Saratzis Athanasios, de Borst Gert J, Swerdlow Daniel I, van der Graaf Yolanda, van Rij Andre M, Carey David J, Elmore James R, Tromp Gerard, Kuivaniemi Helena, Sayers Robert D, Samani Nilesh J, Bown Matthew J, Humphries Steve E

Abstract excerpt

Importance: Risk factors for abdominal aortic aneurysm (AAA) are largely unknown, which has hampered the development of nonsurgical treatments to alter the natural history of disease. Objective: To investigate the association between lipid-associated single-nucleotide polymorphisms (SNPs) and AAA risk. Design, Setting, and Participants: Genetic risk scores, composed of lipid trait-associated SNPs, were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, HDL

Share to Cholesterol, LDL

Share to Genome-Wide Association Study

Share to Hypolipidemic Agents

Share to Lipid Metabolism

Share to Mendelian Randomization Analysis

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 29188294
DOI: 10.1001/jamacardio.2017.4293
PMCID: PMC5833524

Genes

PCSK9
CETP
HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis.PMID 29188294Read ↗

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic targetSemantic proximity Read ↗

Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study.Semantic proximity Read ↗

Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study.Semantic proximity Read ↗

Lipoprotein (a) is associated with increased risk of Abdominal Aortic AneurysmSemantic proximity Read ↗

Mendelian randomization analysis of the causal relationship between serum metabolites and thoracic aortic aneurysm.Semantic proximity Read ↗

Shared Genetic Susceptibility between Abdominal Aortic Aneurysm and Cardiometabolic TraitsSemantic proximity Read ↗

Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights<i>PCSK9</i>as a therapeutic targetSemantic proximity Read ↗

Deciphering the Role of Metformin in Abdominal Aortic Aneurysm Progression: Insights from Two-Step Mendelian Randomization and Colocalization AnalysisSemantic proximity Read ↗

Differential Risk Profiles of Incident Abdominal Aortic Aneurysms in Specific Subgroups: A Large Cohort-based Study.Semantic proximity Read ↗

Genetic evidence for lifestyle and cardiometabolic factors on the risk of aortic aneurysms: A comprehensive Mendelian randomization study.Semantic proximity Read ↗

Understanding the pathogenesis of abdominal aortic aneurysmsSemantic proximity Read ↗

The genetics of abdominal aortic aneurysms: a comprehensive meta-analysis involving eight candidate genes in over 16,700 patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.