Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combination of biological aging and genetic risk helps identify at-risk population of thoracic aortic aneurysms: insight from a prospective cohort study of UK Biobank.

International journal of surgery (London, England) - 1 Dec 2025

Xu Jiatang, Hu Zhensheng, Liu Hongze, Su Yangfan, Shen Runnan, Xie Chaoyu, Zhou Yi, Huang Kai

Abstract excerpt

BACKGROUND: Both age and genetic risk are associated with risk of thoracic aortic aneurysms (TAA). This study seeks to explore the association between phenotypic age acceleration (PhenoAgeAccel), a novel biomarker of aging, and risk of TAA, as well as to conduct risk stratification for TAA based on PhenoAgeAccel and genetic risk. METHODS: A total of 406 750 participants from the prospective cohort of UK Biobank...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Aneurysm, Thoracic

Share to Biological Specimen Banks

Share to Biomarkers

Share to Risk Assessment

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 40576428
DOI: 10.1097/JS9.0000000000002898
PMCID: PMC12695392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combination of biological aging and genetic risk helps identify at-risk population of thoracic aortic aneurysms: insight from a prospective cohort study of UK Biobank.PMID 40576428Read ↗

Accelerated biological aging, genetic susceptibility, and lifestyle in relation to abdominal aortic aneurysm: A prospective study.Semantic proximity Read ↗

Clinical Biomarker-Based Biological Aging and the Risk of Abdominal Aortic Aneurysm: A Prospective Cohort StudySemantic proximity Read ↗

Biological age acceleration and interaction with genetic predisposition in the risk of type 2 diabetes and coronary artery disease.Semantic proximity Read ↗

Associations between phenotypic age and carotid atherosclerosis among the general population: evidence from a multi-stage study.Semantic proximity Read ↗

Differential Risk Profiles of Incident Abdominal Aortic Aneurysms in Specific Subgroups: A Large Cohort-based Study.Semantic proximity Read ↗

Combination of Biological Aging and Genetic Susceptibility Helps Identifying At-Risk Population of Venous Thromboembolism: A Prospective Cohort Study of 394 041 Participants.Semantic proximity Read ↗

Genetic evidence for the causal linkage between telomere length and aortic aneurysm risk: A Mendelian randomisation study.Semantic proximity Read ↗

Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences.Semantic proximity Read ↗

Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans.Semantic proximity Read ↗

Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran ProgramSemantic proximity Read ↗

Genome-wide Association Study of Thoracic Aortic Aneurysm and Dissection in the Million Veteran ProgramSemantic proximity Read ↗

DNA Methylation-estimated Phenotypes, Telomere length, Aging and Risk of Intracranial Aneurysms: Evidence from genetic studiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.