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Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate

30 Jun 2023

Abstract excerpt

Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral lifecycle. While initially antigenically indistinguishable from virions, ECs readily convert to an expanded conformation at moderate temperatures. In the closely related poliovirus, these...

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PMID: 37390009
DOI: 10.1099/jgv.0.001867

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