Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection.

doi:10.1128/JVI.01586-16

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Article

Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection.

Journal of virology - 15 Feb 2017

Adeyemi Oluwapelumi O, Nicol Clare, Stonehouse Nicola J, Rowlands David J

Abstract excerpt

Poliomyelitis is a highly infectious disease caused by poliovirus (PV). It can result in paralysis and may be fatal. Integrated global immunization programs using live-attenuated oral (OPV) and/or inactivated (IPV) PV vaccines have systematically reduced its spread and paved the way for eradication. Immunization will continue posteradication to ensure against reintroduction of the disease, but there are biosafety...

Topics

Adaptation, Biological
Animals
Antigens, Viral
Biological Evolution
Capsid
Capsid Proteins
Cell Line
Genome, Viral
Humans
Mice
Models, Molecular
Mutation
Poliovirus
Protein Conformation
Protein Stability
Structure-Activity Relationship
Temperature
Thermodynamics

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Identifiers

PMID: 27928008
DOI: 10.1128/JVI.01586-16
PMCID: PMC5286869

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