Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

Abstract excerpt

Foot-and-mouth disease remains a major plague of livestock and outbreaks are often economically catastrophic. Current inactivated virus vaccines require expensive high containment facilities for their production and maintenance of a cold-chain for their activity. We have addressed both of these major drawbacks. Firstly we have developed methods to efficiently express recombinant empty capsids. Expression...

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