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Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccines

8 Jan 2021

Abstract excerpt

Global vaccination programs using live-attenuated oral and inactivated polio vaccine (OPV and IPV) have almost eradicated poliovirus (PV) but these vaccines or their production pose significant risk in a polio-free world. Recombinant PV virus-like particles (VLPs), lacking the viral genome, represent safe next-generation vaccines, however their production requires optimisation. Here we present an efficient...

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PMID: 33420068
DOI: 10.1038/s41541-020-00267-3

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