Article

Production of antigenically stable enterovirus A71 virus-like particles in <i>Pichia pastoris</i> as a vaccine candidate

2023-02-02

Abstract excerpt

Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral lifecycle. While initially antigenically indistinguishable from virions, ECs readily convert to an expanded conformation at moderate temperatures. In the closely related poliovirus, these conformati...

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Literature Corpus work: ead2947f-f08f-5772-8c0a-13201d0c60bf
DOI: 10.1101/2023.01.30.526315

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