Back to search

Article

Protease-independent production of poliovirus virus-like particles in <i>Pichia pastoris</i> : Implications for efficient vaccine development and insights into capsid assembly

2022-09-16

Abstract excerpt

The production of enterovirus virus-like particles (VLPs) which lack the viral genome have great potential as vaccines for a number of diseases, such as poliomyelitis and hand, foot-and-mouth disease. These VLPs can mimic empty capsids, which are antigenically indistinguishable from mature virions, produced naturally during viral infection. Both in infection and in vitro, capsids and VLPs are generated by the clea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3f5ea90e-c0fc-5404-a172-ceb697e96cb5
DOI
10.1101/2022.09.16.508263
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Protease-independent production of poliovirus virus-like particles in <i>Pichia pastoris</i> : Implications for efficient vaccine development and insights into capsid assemblyDOI 10.1101/2022.09.16.508263
Production of antigenically stable enterovirus A71 virus-like particles in <i>Pichia pastoris</i> as a vaccine candidateSemantic proximity
Comparative Molecular Biology Approaches for the Production of Poliovirus Virus-Like Particles Using Pichia pastorisSemantic proximity
Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidateSemantic proximity
Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine AntigenSemantic proximity
Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccinesSemantic proximity
Risk-free polio vaccine: Recombinant expression systems for production of stabilised virus-like particlesSemantic proximity
Expression, purification and characterization of enterovirus-71 virus-like particlesSemantic proximity
N-terminal VP1 truncations favor <i>T</i> =1 norovirus-like particlesSemantic proximity
N-terminal VP1 Truncations Favor T = 1 Norovirus-Like ParticlesSemantic proximity
Low levels of foot-and-mouth disease virus 3C protease expression are required to achieve optimal capsid protein expression and processing in mammalian cellsSemantic proximity
Virus-like particle vaccines for poliovirus types 1, 2, and 3 with enhanced thermostability expressed in insect cellsSemantic proximity
Development and characterization of an enterovirus 71 (EV71) virus-like particles (VLPs) vaccine produced in Pichia pastorisSemantic proximity
Select a neighboring publication to make it the new centre.