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Single-Nucleus and Spatial Transcriptomics Revealing Host Response Differences Triggered by Mutated Virus in Severe Dengue.

Viruses - 15 Nov 2024

Chen Qian, Yuan Yizhen, Cai Fangzhou, Li Zhe, Wei Qiang, Wang Wei

Abstract excerpt

Dengue virus (DENV) infection causes various disease manifestations ranging from an asymptomatic state to severe, life-threatening dengue. Despite intensive research, the molecular mechanisms underlying the abnormal host responses and severe disease symptoms caused by evolved DENV strains is not fully understood. First, the spatial structure of mutant DENV was compared via in silico molecular modeling analysis....

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PMID: 39599894
DOI: 10.3390/v16111779
PMCID: PMC11599075

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