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Emergence and increased epidemic potential of dengue variants with the NS5V357E mutation after consecutive years of transmission

11 Oct 2024

Abstract excerpt

Arboviruses can intensify epidemics by acquiring single nucleotide variants, leading to clade replacement and severe outbreaks. We investigated dengue virus serotype 2 evolution in consecutive outbreaks from 2001 to 2003 in Taiwan, coinciding with overwintering and increased epidemic severity. The virus evolved from the early-epidemic strain (Ia) to the late-epidemic strains (Ib and II), featuring three amino...

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PMID: 39524326
DOI: 10.1016/j.isci.2024.110899

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