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A Mouse-Adapted CHIKV Strain Harboring E2-K200R and Non-Structural Mutations Exhibits Enhanced Pathogenicity in Multiple Rodent Models.

Viruses - 12 Apr 2026

Tang Cong, Li Bai, Huang Qing, Yang Yun, Yu Wenhai, Zhou Yanan, Wu Daoju, Yang Hao, Wang Haixuan, Wang Junbin, Lu Shuaiyao

Abstract excerpt

Chikungunya virus (CHIKV) pathogenesis research has long been constrained by the lack of suitable immunocompetent rodent models. Through serial passaging in A129 and C57BL/6 mice, we obtained an adapted strain (CHIKV-Adapt) harboring an E2-K200R substitution along with non-structural protein mutations. Phenotypic analysis in C57BL/6 mice, BALB/c mice, and hamster models demonstrated that compared to the wild-type...

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Identifiers

PMID: 42043248
DOI: 10.3390/v18040459
PMCID: PMC13120490

Genes

MXRA8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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