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Warmer Ambient Air Temperatures Reduce Nasal Turbinate and Brain Infection, But Increase Lung Inflammation in the K18-hACE2 Mouse Model of COVID-19

2022-08-08

Abstract excerpt

Warmer climatic conditions have been associated with a reduction in disease caused by SARS-CoV-2. Herein we infected K18-hACE2 mice housed at the standard animal house temperature of 22ºC, or at 31ºC, which is considered to be thermoneutral for mice. On day 2 post infection mice housed at 31ºC showed reduced viral loads in nasal turbinates, consistent with increased mucociliary clearance at the warmer ambient te...

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Literature Corpus work: d30e5135-9201-5fe1-aace-a805e8aef3a4
DOI: 10.2139/ssrn.4181455

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