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Article

Measurements of Intrahost Viral Diversity Are Extremely Sensitive to Systematic Errors in Variant Calling.

Journal of virology - 1 Aug 2016

McCrone John T, Lauring Adam S

Abstract excerpt

UNLABELLED: With next-generation sequencing technologies, it is now feasible to efficiently sequence patient-derived virus populations at a depth of coverage sufficient to detect rare variants. However, each sequencing platform has characteristic error profiles, and sample collection, target amplification, and library preparation are additional processes whereby errors are introduced and propagated. Many studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

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Identifiers

PMID: 27194763
DOI: 10.1128/JVI.00667-16
PMCID: PMC4944299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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