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Article

Viral population analysis and minority-variant detection using short read next-generation sequencing.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Mar 2013

Watson Simon J, Welkers Matthijs R A, Depledge Daniel P, Coulter Eve, Breuer Judith M, de Jong Menno D, Kellam Paul

Abstract excerpt

RNA viruses within infected individuals exist as a population of evolutionary-related variants. Owing to evolutionary change affecting the constitution of this population, the frequency and/or occurrence of individual viral variants can show marked or subtle fluctuations. Since the development of massively parallel sequencing platforms, such viral populations can now be investigated to unprecedented resolution. A...

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Identifiers

PMID: 23382427
DOI: 10.1098/rstb.2012.0205
PMCID: PMC3678329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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