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Single-Molecule Telomere Assay via Optical Mapping (SMTA-OM) Can Potentially Define the ALT Positivity of Cancer

16 Jun 2023

Abstract excerpt

Telomeres play an essential role in protecting the ends of linear chromosomes and maintaining the integrity of the human genome. One of the key hallmarks of cancers is their replicative immortality. As many as 85-90% of cancers activate the expression of telomerase (TEL+) as the telomere maintenance mechanism (TMM), and 10-15% of cancers utilize the homology-dependent repair (HDR)-based Alternative Lengthening of...

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Share to Advanced biosensing and bioanalysis techniques
Share to Chromosomal and Genetic Variations
Share to Telomeres, Telomerase, and Senescence

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PMID: 37372458
DOI: 10.3390/genes14061278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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