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Article

Dysregulation of SWI/SNF Chromatin Remodelers in NSCLC: Its Influence on Cancer Therapies including Immunotherapy.

Biomolecules - 13 Jun 2023

Shi Yijiang, Shin Daniel Sanghoon

Abstract excerpt

Lung cancer is the leading cause of cancer death worldwide. Molecularly targeted therapeutics and immunotherapy revolutionized the clinical care of NSCLC patients. However, not all NSCLC patients harbor molecular targets (e.g., mutated EGFR), and only a subset benefits from immunotherapy. Moreover, we are lacking reliable biomarkers for immunotherapy, although PD-L1 expression has been mainly used for guiding...

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Identifiers

PMID: 37371564
DOI: 10.3390/biom13060984
PMCID: PMC10296130

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