Article

ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS- STING Pathway in Non-Small Cell Lung Cancer

2023-09-08

Abstract excerpt

<h4>Purpose: </h4> Lung cancer is a major cause of morbidity and mortality globally, necessitating the identification of predictive markers for effective immunotherapy. Mutations in SWI/SNF chromatin remodeling complex genes were reported sensitized human tumors to immune checkpoint inhibitors (ICIs), but the underlying mechanisms are unclear. This study aim to investigates the association between SWI/SNF gene ARI...

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Literature Corpus work: 49f200b6-1f0c-5bab-a54d-2eec38028301
DOI: 10.21203/rs.3.rs-3321257/v1

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