Article
Role of Reduced Bdnf Expression in Novel Apc Mutant Allele-induced Intestinal and Colonic Tumorigenesis in Mice.
In vivo (Athens, Greece) - 1 Jan 2000
Gok Ayşenur, Işik Aynur, Bakir Sinem, Uzun Sarp, Guner Gunes, Ozcan Ozge, Cerci Baris, Onbaşilar Ilyas, Akyol Aytekin
Abstract excerpt
BACKGROUND/AIM: Brain-derived neurotrophic factor (BDNF) is a growth factor of the neurotrophin family. Recent studies indicate that its expression is regulated by Wnt/β-catenin signaling. In this study, we aimed to examine the effects of reduced Bdnf levels in an Apc mutant intestinal/colonic tumor mouse model. MATERIALS AND METHODS: We crossed Apc+/- and Bdnf+/- C57BL/6 mice. After genotyping the litters,...
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