Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in Japanese.

Circulation journal : official journal of the Japanese Circulation Society - 1 Mar 2010

Hiura Yumiko, Tabara Yasuharu, Kokubo Yoshihiro, Okamura Tomonori, Goto Yoichi, Nonogi Hiroshi, Miki Tetsuro, Tomoike Hitonobu, Iwai Naoharu

Abstract excerpt

BACKGROUND: The association between single nucleotide polymorphisms (SNPs) at 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and low-density lipoprotein-cholesterol (LDL-C) levels has been well replicated in genome-wide association studies (GWAS) of white populations. Recently, the commo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, LDL

Share to Diabetes Mellitus

Share to Hydroxymethylglutaryl CoA Reductases

Share to Hypertension

Share to Myocardial Infarction

Share to Smoking

Source

Identifiers

PMID: 20145341
DOI: 10.1253/circj.cj-09-0790

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20145341-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in Japanese.PMID 20145341Read ↗

Effect of HMGCR variant alleles on low-density lipoprotein cholesterol-lowering response to atorvastatin in healthy Korean subjects.Semantic proximity Read ↗

Lipid-associated genetic polymorphisms are associated with FBP and LDL-c levels among myocardial infarction patients in Chinese population.Semantic proximity Read ↗

Association of HMGCR rs17671591 and rs3761740 with lipidemia and statin response in Uyghurs and Han Chinese.Semantic proximity Read ↗

The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease.Semantic proximity Read ↗

Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.Semantic proximity Read ↗

Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.Semantic proximity Read ↗

CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men.Semantic proximity Read ↗

High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Impedance of Cholesterol BiosynthesisSemantic proximity Read ↗

Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis.Semantic proximity Read ↗

Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population: the Suita study.Semantic proximity Read ↗

SLC12A3 variants modulate LDL cholesterol levels in the Mongolian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.