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Causal relationship between drug target genes of LDL-cholesterol and coronary artery disease: Drug Target Mendelian Randomization Study

2024-10-30

Abstract excerpt

<title>Abstract</title> <p>Background High LDL-cholesterol (LDL-C) is a well-known risk factor for coronary artery disease (CAD). <italic>PCSK9, HMGCR, NPC1L1, ACLY</italic>, and <italic>LDLR</italic> gene have been reported as lipid lowering drug genes related to LDL-C lowering. However relevant Asian studies were rare. Methods We examined the causality between LDL-c drug target genes and CAD using Korean and...

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Literature Corpus work
ee14d5ea-a5ef-5d77-843c-84e38e021eb4
DOI
10.21203/rs.3.rs-5294164/v1
Open publication

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Causal relationship between drug target genes of LDL-cholesterol and coronary artery disease: Drug Target Mendelian Randomization StudyDOI 10.21203/rs.3.rs-5294164/v1
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