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Article

Genomewide screen for modulators of evolvability under toxic antibiotic exposure.

Antimicrobial agents and chemotherapy - 1 Jul 2013

Méhi Orsolya, Bogos Balázs, Csörgo Bálint, Pál Csaba

Abstract excerpt

Antibiotic resistance is generally selected within a window of concentrations high enough to inhibit wild-type growth but low enough for new resistant mutants to emerge. We studied de novo evolution of resistance to ciprofloxacin in an Escherichia coli knockout library. Five null mutations had little or no effect on intrinsic antibiotic susceptibility but increased the upper antibiotic dosage to which initially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23669383
DOI: 10.1128/AAC.02454-12
PMCID: PMC3697378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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