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Article

PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma.

The Journal of pathology - 1 Aug 2023

Choi Sangjoon, Kim Hyunjin, Heo You Jeoung, Kang So Young, Ahn Soomin, Lee Jeeyun, Kim Kyoung-Mee

Abstract excerpt

PIK3CA mutations in cancer regulate tumour immunogenicity. Given that PIK3CA mutation subtypes influence therapeutic responses to AKT inhibitor and that H1047R mutation confers selective growth advantages after immunotherapy, we hypothesised that immune phenotypes may depend on PIK3CA mutation subtypes. We investigated 133 gastric cancers (GCs) harbouring PIK3CA mutation [21 E542K (15.8%), 36 E545X (27.1%), 26...

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Identifiers

PMID: 37341658
DOI: 10.1002/path.6134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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