Article
Phenotypic immune characterization of gastric and esophageal adenocarcinomas reveals profound immune suppression in esophageal tumor locations.
Frontiers in immunology - 1 Jan 2024
Groen-van Schooten Tessa S, Harrasser Micaela, Seidel Jens, Bos Emma N, Fleitas Tania, van Mourik Monique, Pouw Roos E, Goedegebuure Ruben S A, Doeve Benthe H, Sanders Jasper, Bos Joris, van Berge Henegouwen Mark I, Thijssen Victor L J L, van Grieken Nicole C T, van Laarhoven Hanneke W M, de Gruijl Tanja D, Derks Sarah
Abstract excerpt
Background: Tumors in the distal esophagus (EAC), gastro-esophageal junction including cardia (GEJAC), and stomach (GAC) develop in close proximity and show strong similarities on a molecular and cellular level. However, recent clinical data showed that the effectiveness of chemo-immunotherapy is limited to a subset of GEAC patients and that EACs and GEJACs generally benefit less from checkpoint inhibition...
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