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Article

Epstein-Barr virus-associated gastric cancer reveals intratumoral heterogeneity of PIK3CA mutations.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2017

Böger C, Krüger S, Behrens H M, Bock S, Haag J, Kalthoff H, Röcken C

Abstract excerpt

Background: Recent whole-genome sequencing identified four molecular subtypes of gastric cancer (GC), of which the subgroup of Epstein-Barr virus-associated GC (EBVaGC) showed a significant enrichment of PIK3CA mutations. We here aimed to validate independently the enrichment of PIK3CA mutations in EBVaGC of a Central European GC cohort, to correlate EBV status with clinico-pathological patient characteristics...

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Identifiers

PMID: 28453696
DOI: 10.1093/annonc/mdx047
PMCID: PMC5406766

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