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Article

GluK2 Is a Target for Gene Therapy in Drug‐Resistant Temporal Lobe Epilepsy

21 Jun 2023

Abstract excerpt

OBJECTIVE: Temporal lobe epilepsy (TLE) is characterized by recurrent seizures generated in the limbic system, particularly in the hippocampus. In TLE, recurrent mossy fiber sprouting from dentate gyrus granule cells (DGCs) crea an aberrant epileptogenic network between DGCs which operates via ectopically expressed GluK2/GluK5-containing kainate receptors (KARs). TLE patients are often resistant to anti-seizure...

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PMID: 37341588
DOI: 10.1002/ana.26723

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