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Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients.

Therapeutic drug monitoring - 1 Jun 2014

Inoue Kazuyuki, Suzuki Eri, Yazawa Rei, Yamamoto Yoshiaki, Takahashi Toshiki, Takahashi Yukitoshi, Imai Katsumi, Koyama Seiichi, Inoue Yushi, Tsuji Daiki, Hayashi Hideki, Itoh Kunihiko

Abstract excerpt

BACKGROUND: Valproic acid (VPA) is widely used to treat various types of epilepsy. Interindividual variability in VPA pharmacokinetics may arise from genetic polymorphisms of VPA-metabolizing enzymes. This study aimed to examine the relationships between plasma VPA concentrations and the -161C>T single nucleotide polymorphism in uridine diphosphate glucuronosyltransferase (UGT) 2B7 genes in pediatric epilepsy...

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Source

Identifiers

PMID: 24365988
DOI: 10.1097/FTD.0000000000000012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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