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Article

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2011

Matthews Erin E, Thévenin Damien, Rogers Julia M, Gotow Lisa, Lira Paul D, Reiter Lawrence A, Brissette William H, Engelman Donald M

Abstract excerpt

We report how rotational variations in transmembrane (TM) helix interactions participate in the activity states of the thrombopoietin receptor (TpoR), a type 1 cytokine receptor that controls the production of blood platelets. We also explore the mechanism of small-molecule agonists that do not mimic the natural ligand. We show, by a combination of cysteine cross-linking, alanine-scanning mutagenesis, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21402716
DOI: 10.1096/fj.10-178673
PMCID: PMC3114528

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