Article
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.
Blood - 4 Feb 2010
Pecquet Christian, Staerk Judith, Chaligné Ronan, Goss Valerie, Lee Kimberly A, Zhang Xiaowu, Rush John, Van Hees Joanne, Poirel Hélène A, Scheiff Jean-Marie, Vainchenker William, Giraudier Stéphane, Polakiewicz Roberto D, Constantinescu Stefan N
Abstract excerpt
Constitutively active JAK2V617F and thrombopoietin receptor (TpoR) W515L/K mutants are major determinants of human myeloproliferative neoplasms (MPNs). We show that a TpoRW515 mutation (W515A), which we detected in 2 myelofibrosis patients, and the Delta5TpoR active mutant, where the juxtamembrane R/KW(515)QFP motif is deleted, induce a myeloproliferative phenotype in mouse bone marrow reconstitution experiments....
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