Article
Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure (London, England : 1993) - 6 Jun 2017
Pal Kuntal, Bandyopadhyay Abhishek, Zhou X Edward, Xu Qingping, Marciano David P, Brunzelle Joseph S, Yerrum Smitha, Griffin Patrick R, Vande Woude George, Melcher Karsten, Xu H Eric
Abstract excerpt
The nuclear pore complex subunit TPR is found in at least five different oncogenic fusion kinases, including TPR-MET, yet how TPR fusions promote activation of kinases and their oncogenic activities remains poorly understood. Here we report the crystal structure of TPR(2-142), the MET fusion partner of oncogenic TPR-MET. TPR(2-142) contains a continuous 124-residue α helix that forms an antiparallel tetramer from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.