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Article

Inferring the distributions of fitness effects and proportions of strongly deleterious mutations.

G3 (Bethesda, Md.) - 30 Aug 2023

Charmouh Anders P, Bocedi Greta, Hartfield Matthew

Abstract excerpt

The distribution of fitness effects is a key property in evolutionary genetics as it has implications for several evolutionary phenomena including the evolution of sex and mating systems, the rate of adaptive evolution, and the prevalence of deleterious mutations. Despite the distribution of fitness effects being extensively studied, the effects of strongly deleterious mutations are difficult to infer since such...

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PMID: 37337692
DOI: 10.1093/g3journal/jkad140
PMCID: PMC10468728

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