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Article

Dipeptidyl Peptidase 4 Restoration Facilitates Antitumor Immunity in KRAS-LKB1-Mutant Lung Cancer.

Cancer research communications - 1 Dec 2025

Tenma Toshiyuki, Yoshida Ryohei, Yanada Hiraku, Nitanai Kiichi, Nagato Toshihiro, Oyama Kyohei, Sasaki Nobunari, Homme Mizuki, Mori Chie, Ohkuri Takayuki, Ono Yusuke, Tange Shoichiro, Minami Yoshinori, Kobayashi Hiroya, Mizukami Yusuke, Barbie David A, Kitajima Shunsuke, Sasaki Takaaki

Abstract excerpt

KRAS proto-oncogene, GTPase (KRAS)-liver kinase B1 (LKB1)-mutant (KL) non-small cell lung cancer (NSCLC), characterized by a profoundly immunosuppressive tumor microenvironment (TME), is highly resistant to immune checkpoint inhibitors. Despite their high tumor mutation burden, KL tumors exhibit low expression of PD-L1, reduced immune cell infiltration, and suppressed immune signaling pathways. Systematic genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Killer Cells, Natural

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Source

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Identifiers

PMID: 41283988
DOI: 10.1158/2767-9764.CRC-25-0199
PMCID: PMC12709056

Genes

DPP4
KL
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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