Article
A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework.
BMC genomics - 25 Jun 2018
LeBlanc Marissa, Zuber Verena, Thompson Wesley K, Andreassen Ole A, Frigessi Arnoldo, Andreassen Bettina Kulle
Abstract excerpt
BACKGROUND: There is considerable evidence that many complex traits have a partially shared genetic basis, termed pleiotropy. It is therefore useful to consider integrating genome-wide association study (GWAS) data across several traits, usually at the summary statistic level. A major practical challenge arises when these GWAS have overlapping subjects. This is particularly an issue when estimating pleiotropy...
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