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Article

Potential application of elastic nets for shared polygenicity detection with adapted threshold selection.

The international journal of biostatistics - 1 Nov 2023

John Majnu, Lencz Todd

Abstract excerpt

Current research suggests that hundreds to thousands of single nucleotide polymorphisms (SNPs) with small to modest effect sizes contribute to the genetic basis of many disorders, a phenomenon labeled as polygenicity. Additionally, many such disorders demonstrate polygenic overlap, in which risk alleles are shared at associated genetic loci. A simple strategy to detect polygenic overlap between two phenotypes is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36327464
DOI: 10.1515/ijb-2020-0108
PMCID: PMC10154439

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