Article
Across-cohort QC analyses of GWAS summary statistics from complex traits.
European journal of human genetics : EJHG - 1 Jan 2016
Chen Guo-Bo, Lee Sang Hong, Robinson Matthew R, Trzaskowski Maciej, Zhu Zhi-Xiang, Winkler Thomas W, Day Felix R, Croteau-Chonka Damien C, Wood Andrew R, Locke Adam E, Kutalik Zoltán, Loos Ruth J F, Frayling Timothy M, Hirschhorn Joel N, Yang Jian, Wray Naomi R, Visscher Peter M
Abstract excerpt
Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires large genome-wide association meta-analyses (GWAMAs) to maximize statistical power. A trend towards ever-larger GWAMA is likely to continue, yet dealing with summary statistics from hundreds...
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