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Article

Prognostic value of Lynch syndrome, BRAFV600E , and RAS mutational status in dMMR/MSI-H metastatic colorectal cancer in a pooled analysis of Dutch and French cohorts.

Cancer medicine - 1 Aug 2023

Zwart Koen, van der Baan Frederieke H, Cohen Romain, Aparicio Thomas, de la Fouchardiére Christelle, Lecomte Thierry, Punt Cornelis J A, Sefrioui David, Verheijden Rik J, Vink Geraldine R, Wensink G Emerens, Zaanan Aziz, Koopman Miriam, Tougeron David, Roodhart Jeanine M L

Abstract excerpt

BACKGROUND: Current knowledge on prognostic biomarkers (especially BRAFV600E /RAS mutations) in metastatic colorectal cancer (mCRC) is mainly based on mCRC patients with proficient mismatch repair (pMMR) tumors. It is uncertain whether these biomarkers have the same prognostic value in mCRC patients with deficient mismatch repair (dMMR) tumors. METHODS: This observational cohort study combined a population-based...

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PMID: 37326121
DOI: 10.1002/cam4.6223
PMCID: PMC10469760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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