Article
Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2014
Venderbosch Sabine, Nagtegaal Iris D, Maughan Tim S, Smith Christopher G, Cheadle Jeremy P, Fisher David, Kaplan Richard, Quirke Philip, Seymour Matthew T, Richman Susan D, Meijer Gerrit A, Ylstra Bauke, Heideman Danielle A M, de Haan Anton F J, Punt Cornelis J A, Koopman Miriam
Abstract excerpt
PURPOSE: To determine the prevalence and prognostic value of mismatch repair (MMR) status and its relation to BRAF mutation (BRAF(MT)) status in metastatic colorectal cancer (mCRC). EXPERIMENTAL DESIGN: A pooled analysis of four phase III studies in first-line treatment of mCRC (CAIRO, CAIRO2, COIN, and FOCUS) was performed. Primary outcome parameter was the hazard ratio (HR) for median progression-free survival...
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