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Real-world evaluation of treatment patterns and clinical outcomes in patients with BRAF-V600E metastatic colorectal cancer (mCRC) in Canada.

Cancer treatment and research communications - 1 Jan 2025

Phillips William J, Marginean Horia, Alrehaili Mohammad, Abdelrahim Arwa Ahmed, Asmis Tim, Vickers Mike, Yeung Benjamin, Lo Bryan, Goodwin Rachel

Abstract excerpt

BACKGROUND: BRAF V600E mutations are identified in 10 % of metastatic colorectal cancer (mCRC) cases. In this project, we evaluated the clinicopathologic features and natural history of patients with BRAF mutant (BRAF-mt) mCRC prior to era of BRAF targeted therapy. METHODS: This is a retrospective project evaluating patients with diagnosed with mCRC with an identified BRAF V600E mutation between January 1, 2015...

Topics

Humans
Female
Colorectal Neoplasms
Male
Proto-Oncogene Proteins B-raf
Aged
Retrospective Studies
Canada
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged, 80 and over

Neoplasm Metastasis

Antineoplastic Combined Chemotherapy Protocols

Source

Identifiers

PMID: 40147102
DOI: 10.1016/j.ctarc.2025.100896

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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