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Article

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells.

Journal of neuro-oncology - 1 May 2010

Ayuso-Sacido Angel, Moliterno Jennifer A, Kratovac Sebila, Kapoor Gurpreet S, O'Rourke Donald M, Holland Eric C, García-Verdugo Jose Manuel, Roy Neeta S, Boockvar John A

Abstract excerpt

Recent evidence supports the notion that transformation of undifferentiated neural stem cell (NSC) precursors may contribute to the development of glioblastoma multiforme (GBM). The over-expression and mutation of the epidermal growth factor receptor (EGFR), along with other cellular pathway mutations, plays a significant role in GBM maintenance progression. Though EGFR signaling is important in determining...

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Source

Identifiers

PMID: 19855928
DOI: 10.1007/s11060-009-0035-x

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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