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An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity

14 Jun 2023

Abstract excerpt

Most drugs used to treat viral disease target a virus-coded product. They inhibit a single virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals can overcome these limitations. The broad-spectrum activity achieved by host targeting can be especially useful in combating emerging viruses and for treatment of diseases caused by multiple viral pathogens, such as opportunistic...

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PMID: 37317966
DOI: 10.1172/jci158978

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