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Sirtuin 2 promotes human cytomegalovirus replication by regulating cell cycle progression

2 Nov 2023

Abstract excerpt

ABSTRACT The ability to modulate host cell cycle progression is a requirement of many human viruses in order to facilitate their replication and propagation. Nuclear-replicating DNA viruses frequently stall the host cell cycle in G1 to avoid competition with host DNA replication. Among these viruses is human cytomegalovirus (HCMV), a prevalent beta-herpesvirus. Here, we discover a pro-viral mechanism that employs...

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PMID: 37916830
DOI: 10.1128/msystems.00510-23

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